Recent Publications

Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, Hollingsworth MA, Brooks CL, Radhakrishnan P.Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Mol Cancer Ther. 2024. PMID: 38394685

Duncan KD, Pětrošová H, Lum JJ, Goodlett DR.Mass spectrometry imaging methods for visualizing tumor heterogeneity. Curr Opin Biotechnol. 2024. PMID: 38310648

Hofstaedter CE, Chandler CE, Met CM, Gillespie JJ, Harro JM, Goodlett DR, Rasko DA, Ernst RK.Divergent Pseudomonas aeruginosa LpxO enzymes perform site-specific lipid A 2-hydroxylation. mBio. 2024. PMID: 38131669

Mohammed Y, Tran K, Carlsten C, Ryerson C, Wong A, Lee T, Cheng MP, Vinh DC, Lee TC, Winston BW, Sweet D, Boyd JH, Walley KR, Haljan G, McGeer A, Lamontagne F, Fowler R, Maslove D, Singer J, Patrick DM, Marshall JC, Murthy S, Jain F, Borchers CH, Goodlett DR, Levin A, Russell JA.Proteomic Evolution from Acute to Post-COVID-19 Conditions. J Proteome Res. 2024. PMID: 38048423

Mikhael A, Hardie D, Smith D, Pětrošová H, Ernst RK, Goodlett DR.Structural Elucidation of Intact Rough-type Lipopolysaccharides Using Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots. Anal Chem. 2023. PMID: 37943784

Houston S, Gomez A, Geppert A, Eshghi A, Smith DS, Waugh S, Hardie DB, Goodlett DR, Cameron CE.Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection. Sci Rep. 2023. PMID: 37880309

Haq S, Oyler BL, Williams E, Khan MM, Goodlett DR, Bachvaroff T, Place AR.Investigating A Multi-Domain Polyketide Synthase in Amphidinium carterae. Mar Drugs. 2023. PMID: 37623706

MacPherson S, Duncan KD, Goodlett DR, Lum JJ.Strategies for uncovering stable isotope tracing patterns between cell populations. Curr Opin Biotechnol. 2023. PMID: 37619527

Mikhael A, Hardie D, Smith D, Pětrošová H, Ernst RK, Goodlett DR.Structural Elucidation of Intact Rough-Type Lipopolysaccharides using Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots. bioRxiv. 2023. PMID: 37461651

Pětrošová H, Mikhael A, Culos S, Giraud-Gatineau A, Gomez AM, Sherman ME, Ernst RK, Cameron CE, Picardeau M, Goodlett DR.Lipid A structural diversity among members of the genus Leptospira. Front Microbiol. 2023. PMID: 37303810

Yang H, Sherman ME, Koo CJ, Treaster LM, Smith JP, Gallaher SG, Goodlett DR, Sweet CR, Ernst RK.Structure Determination of Lipid A with Multiple Glycosylation Sites by Tandem MS of Lithium-Adducted Negative Ions. J Am Soc Mass Spectrom. 2023. PMID: 37184080

Eshghi A, Xie X, Hardie D, Chen MX, Izaguirre F, Newman R, Zhu Y, Kelly RT, Goodlett DR.Sample Preparation Methods for Targeted Single-Cell Proteomics. J Proteome Res. 2023. PMID: 37093777

Bedran G, Gasser HC, Weke K, Wang T, Bedran D, Laird A, Battail C, Zanzotto FM, Pesquita C, Axelson H, Rajan A, Harrison DJ, Palkowski A, Pawlik M, Parys M, O'Neill JR, Brennan PM, Symeonides SN, Goodlett DR, Litchfield K, Fahraeus R, Hupp TR, Kote S, Alfaro JA.The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I-Associated Peptides. Cancer Immunol Res. 2023. PMID: 36961404

Mohammed Y, Goodlett D, Borchers CH.Bioinformatics Tools and Knowledgebases to Assist Generating Targeted Assays for Plasma Proteomics. Methods Mol Biol. 2023. PMID: 36781806

Mohammed Y, Goodlett D, Borchers CH.Absolute Quantitative Targeted Proteomics Assays for Plasma Proteins. Methods Mol Biol. 2023. PMID: 36781801

Prakash R, Goodlett DW, Varghese S, Andrys J, Gbadamosi FA, Arriaza RH, Patel M, Tiwari PB, Borowski T, Chruszcz M, Shimizu LS, Upadhyay G.Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928. Bioorg Med Chem. 2023. PMID: 36680947

Välikangas T, Suomi T, Chandler CE, Scott AJ, Tran BQ, Ernst RK, Goodlett DR, Elo LL.Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach. Nat Commun. 2022. PMID: 36550114

Sherman ME, Smith RD, Gardner FM, Goodlett DR, Ernst RK.A Sensitive GC-MS Method for Quantitation of Lipid A Backbone Components and Terminal Phosphate Modifications. J Am Soc Mass Spectrom. 2022. PMID: 36326685

Yang H, Smith RD, Sumner KP, Goodlett DR, Johnson JK, Ernst RK.A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens. Microbiol Spectr. 2022. PMID: 36255333

Zik JJ, Yoon SH, Guan Z, Stankeviciute Skidmore G, Gudoor RR, Davies KM, Deutschbauer AM, Goodlett DR, Klein EA, Ryan KR.Caulobacter lipid A is conditionally dispensable in the absence of fur and in the presence of anionic sphingolipids. Cell Rep. 2022. PMID: 35649364

Rocheleau GLY, Lee T, Mohammed Y, Goodlett D, Burns K, Cheng MP, Tran K, Sweet D, Marshall J, Slutsky AS, Murthy S, Singer J, Patrick DM, Du B, Peng Z, Lee TC, Boyd JH, Walley KR, Lamontagne F, Fowler R, Winston BW, Haljan G, Vinh DC, McGeer A, Maslove D, Patrigeon SP, Mann P, Donohoe K, Hernandez G, Russell JA.Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Crit Care Med. 2022. PMID: 35607951

Yang H, Smith RD, Chandler CE, Johnson JK, Jackson SN, Woods AS, Scott AJ, Goodlett DR, Ernst RK.Lipid A Structural Determination from a Single Colony. Anal Chem. 2022. PMID: 35576511

Weke K, Kote S, Faktor J, Al Shboul S, Uwugiaren N, Brennan PM, Goodlett DR, Hupp TR, Dapic I.DIA-MS proteome analysis of formalin-fixed paraffin-embedded glioblastoma tissues. Anal Chim Acta. 2022. PMID: 35397901

Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR.Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022. PMID: 35172604

Dapic I, Uwugiaren N, Kers J, Mohammed Y, Goodlett DR, Corthals G.Evaluation of Fast and Sensitive Proteome Profiling of FF and FFPE Kidney Patient Tissues. Molecules. 2022. PMID: 35164409

Mohammed Y, Goodlett DR, Cheng MP, Vinh DC, Lee TC, Mcgeer A, Sweet D, Tran K, Lee T, Murthy S, Boyd JH, Singer J, Walley KR, Patrick DM, Quan C, Ismail S, Amar L, Pal A, Bassawon R, Fesdekjian L, Gou K, Lamontagne F, Marshall J, Haljan G, Fowler R, Winston BW, Russell JA.Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19. J Proteome Res. 2022. PMID: 35143212

Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, Ernst RK.A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species. Microbiol Spectr. 2022. PMID: 35107363

Mesa-Perez M, Hamilton PT, Miranda A, Brodie N, O'Sullivan C, Christie J, Ryan BC, Chow RL, Goodlett D, Nelson CJ, Howard PL.Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity. Nucleic Acids Res. 2022. PMID: 35104878

Froehlich BC, Gill HK, Joshi A, Goodlett DR.MS visualization and interpretation software (MS-VIS), a tool for visualizing mass spectra and analysing mass lists. Rapid Commun Mass Spectrom. 2022. PMID: 34997654

Harberts E, Liang T, Yoon SH, Opene BN, McFarland MA, Goodlett DR, Ernst RK.Correction to "Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics". J Proteome Res. 2022. PMID: 34793171

Ernst O, Khan MM, Oyler BL, Yoon SH, Sun J, Lin FY, Manes NP, MacKerell AD Jr, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A.Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics. mSystems. 2021. PMID: 34342534

Pirog A, Faktor J, Urban-Wojciuk Z, Kote S, Chruściel E, Arcimowicz Ł, Marek-Trzonkowska N, Vojtesek B, Hupp TR, Al Shboul S, Brennan PM, Smoleński RT, Goodlett DR, Dapic I.Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples. Talanta. 2021. PMID: 34215064

Chattagul S, Khan MM, Scott AJ, Nita-Lazar A, Ernst RK, Goodlett DR, Sermswan RW.Transcriptomics Analysis Uncovers Transient Ceftazidime Tolerance in Burkholderia Biofilms. ACS Infect Dis. 2021. PMID: 34138549

Alfaro JA, Bohländer P, Dai M, Filius M, Howard CJ, van Kooten XF, Ohayon S, Pomorski A, Schmid S, Aksimentiev A, Anslyn EV, Bedran G, Cao C, Chinappi M, Coyaud E, Dekker C, Dittmar G, Drachman N, Eelkema R, Goodlett D, Hentz S, Kalathiya U, Kelleher NL, Kelly RT, Kelman Z, Kim SH, Kuster B, Rodriguez-Larrea D, Lindsay S, Maglia G, Marcotte EM, Marino JP, Masselon C, Mayer M, Samaras P, Sarthak K, Sepiashvili L, Stein D, Wanunu M, Wilhelm M, Yin P, Meller A, Joo C.The emerging landscape of single-molecule protein sequencing technologies. Nat Methods. 2021. PMID: 34099939

Kalathiya U, Padariya M, Faktor J, Coyaud E, Alfaro JA, Fahraeus R, Hupp TR, Goodlett DR.Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS). Biomolecules. 2021. PMID: 33806612

Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC.Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Sci Immunol. 2021. PMID: 33712473

Bhowmick P, Roome S, Borchers CH, Goodlett DR, Mohammed Y.An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community. J Proteome Res. 2021. PMID: 33683131

Weke K, Singh A, Uwugiaren N, Alfaro JA, Wang T, Hupp TR, O'Neill JR, Vojtesek B, Goodlett DR, Williams SM, Zhou M, Kelly RT, Zhu Y, Dapic I.MicroPOTS Analysis of Barrett's Esophageal Cell Line Models Identifies Proteomic Changes after Physiologic and Radiation Stress. J Proteome Res. 2021. PMID: 33491460

Bansal R, Khan MM, Dasari S, Verma I, Goodlett DR, Manes NP, Nita-Lazar A, Sharma SP, Kumar A, Singh N, Chakraborti A, Gupta V, Dogra MR, Ram J, Gupta A.Proteomic profile of vitreous in patients with tubercular uveitis. Tuberculosis (Edinb). 2021. PMID: 33359883

Sorensen M, Chandler CE, Gardner FM, Ramadan S, Khot PD, Leung LM, Farrance CE, Goodlett DR, Ernst RK, Nilsson E.Rapid microbial identification and colistin resistance detection via MALDI-TOF MS using a novel on-target extraction of membrane lipids. Sci Rep. 2020. PMID: 33299017

Yang H, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ.Streamlined Analysis of Cardiolipins in Prokaryotic and Eukaryotic Samples Using a Norharmane Matrix by MALDI-MSI. J Am Soc Mass Spectrom. 2020. PMID: 32924474

Yang H, Chandler CE, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ.On-Tissue Derivatization of Lipopolysaccharide for Detection of Lipid A Using MALDI-MSI. Anal Chem. 2020. PMID: 32902263

Chandler CE, Harberts EM, Pelletier MR, Thaipisuttikul I, Jones JW, Hajjar AM, Sahl JW, Goodlett DR, Pride AC, Rasko DA, Trent MS, Bishop RE, Ernst RK.Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis. Proc Natl Acad Sci U S A. 2020. PMID: 32868431

Faktor J, Grasso G, Zavadil Kokas F, Kurkowiak M, Mayordomo MY, Kote S, Singh A, Ruidong L, O'Neill JR, Muller P, Goodlett D, Vojtesek B, Hupp T.The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model. Biochim Biophys Acta Gen Subj. 2020. PMID: 32866596

Srzentić K, Fornelli L, Tsybin YO, Loo JA, Seckler H, Agar JN, Anderson LC, Bai DL, Beck A, Brodbelt JS, van der Burgt YEM, Chamot-Rooke J, Chatterjee S, Chen Y, Clarke DJ, Danis PO, Diedrich JK, D'Ippolito RA, Dupré M, Gasilova N, Ge Y, Goo YA, Goodlett DR, Greer S, Haselmann KF, He L, Hendrickson CL, Hinkle JD, Holt MV, Hughes S, Hunt DF, Kelleher NL, Kozhinov AN, Lin Z, Malosse C, Marshall AG, Menin L, Millikin RJ, Nagornov KO, Nicolardi S, Paša-Tolić L, Pengelley S, Quebbemann NR, Resemann A, Sandoval W, Sarin R, Schmitt ND, Shabanowitz J, Shaw JB, Shortreed MR, Smith LM, Sobott F, Suckau D, Toby T, Weisbrod CR, Wildburger NC, Yates JR 3rd, Yoon SH, Young NL, Zhou M.Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2020. PMID: 32812765

Sun D, Böhringer KF, Sorensen M, Nilsson E, Edgar JS, Goodlett DR.Droplet delivery and nebulization system using surface acoustic wave for mass spectrometry. Lab Chip. 2020. PMID: 32760973

Goodlett D, Hung A, Feriozzi A, Lu H, Bekelman JE, Mullins CD.Site engagement for multi-site clinical trials. Contemp Clin Trials Commun. 2020. PMID: 32685765

Ryu SY, Wendt GA, Ernst RK, Goodlett DR.MGMS2: Membrane glycolipid mass spectrum simulator for polymicrobial samples. Rapid Commun Mass Spectrom. 2020. PMID: 32384576

Zhou M, Uwugiaren N, Williams SM, Moore RJ, Zhao R, Goodlett D, Dapic I, Paša-Tolić L, Zhu Y.Sensitive Top-Down Proteomics Analysis of a Low Number of Mammalian Cells Using a Nanodroplet Sample Processing Platform. Anal Chem. 2020. PMID: 32374172

Benti S, Tiwari PB, Goodlett DW, Daneshian L, Kern GB, Smith MD, Uren A, Chruszcz M, Shimizu LS, Upadhyay G.Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. Cancers (Basel). 2020. PMID: 32098321